HemeLB is a high-performance lattice-Boltzmann solver optimized for simulating blood flow through sparse geometries, such as those found in human vasculature. It scales to hundreds of thousands of cores on modern supercomputers.
Traditionally used for modeling cerebral blood flow and vascular remodeling in retinas, HemeLB is now expanding to simulations of full human arterial and venous trees. This work contributes to the fast-growing field of Computational Biomedicine.
This initiative has been primarily developed from the research lab of Prof. Peter V Coveney at University College London.
This tutorial page provides a concise guide to HemeLB documentation and materials.
Project Documentation
View the full document here: HemeLB Documentation
Installation
Tutorial
Project Resources Online
Key Papers
- M.D. Mazzeo & P.V. Coveney, "HemeLB: A high performance parallel lattice-Boltzmann code for large scale fluid flow in complex geometries", Comput. Phys. Commun. (2008). https://doi.org/10.1016/j.cpc.2008.02.013
- D. Groen, J. Hetherington, H.B. Carver, R.W. Nash, M.O. Bernabeu, "Analysing and modelling the performance of the HemeLB lattice-Boltzmann simulation environment", J. Comput. Sci. (2013). https://doi.org/10.1016/j.jocs.2013.03.002
- R.W. Nash, H.B. Carver, M.O. Bernabeu, J. Hetherington, D. Groen, T. Krüger, P.V. Coveney, "Choice of boundary condition for lattice-Boltzmann simulation of moderate-Reynolds-number flow in complex domains", Phys. Rev. E (2014). https://doi.org/10.1103/PhysRevE.89.023303
Papers Using HemeLB
- Q. Zhou, K. Schirrmann, E. Doman, Q. Chen, N. Singh, P. Ravi Selvaganapathy, M.O. Bernabeu, O.E. Jensen, A. Juel, I.L. Chernyavsky, T. Krüger. Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media. Interface Focus 12, 20220037 (2022). Link
- Q. Zhou, T. Perovic, I. Fechner, L.T. Edgar, P.R. Hoskins, H. Gerhardt, T. Krüger, M.O. Bernabeu. Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks. J. R. Soc. Interface 18, 20210113 (2021). Link
- R. Enjalbert, D. Hardman, T. Krüger, M.O. Bernabeu. Compressed vessels bias red blood cell partitioning at bifurcations in a hematocrit-dependent manner: Implications in tumor blood flow. PNAS 118, e2025236118 (2021). Link
- Q. Zhou, J. Fidalgo, M.O. Bernabeu, M.S.N. Oliveira, T. Krüger. Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations. Soft Matter 17, 3619–3633 (2021). Link
- M.O. Bernabeu, J. Köry, J.A. Grogan, B. Markelc, A.B. Ricol, M. d’Avezac, R. Enjalbert, J. Kaeppler, N. Daly, J. Hetherington, T. Krüger, P.K. Maini, J.M. Pitt-Francis, R.J. Muschel, T. Alarcón, H.M. Byrne. Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. PNAS 117, 27811–27819 (2020). Link
- Q. Zhou, J. Fidalgo, L. Calvi, M.O. Bernabeu, P.R. Hoskins, M.S.N. Oliveira, T. Krüger. Spatiotemporal Dynamics of Dilute Red Blood Cell Suspensions in Low-Inertia Microchannel Flow. Biophys. J. 118, 2561–2573 (2020). Link